Dr. Fattahi's PubMed

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2024

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​Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons

Elder NH, Majd A, Bulger EA, Samuel RM, Zholudeva LV, McDevitt TC, Fattahi F. bioRxiv [Preprint]. 2024 Dec 6:2024.12.03.626573. doi: 10.1101/2024.12.03.626573. PMID: 39677634; PMCID: PMC11642877.

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Differentiation of Enteric Nervous System Lineages from Human Pluripotent Stem Cells
Majd H, Richter MN, Samuel RM, Kalantari A, Ramirez JT, Fattahi F. J Vis Exp. 2024 May 17;(207). doi: 10.3791/66133. PMID: 38829111
 

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A call for a unified and multimodal definition of cellular identity in the enteric nervous system.
Majd H, Cesiulis A, Samuel RM, Richter MN, Elder N, Guyer RA, Hao MM, Stamp LA, Goldstein AM, Fattahi F. bioRxiv. 2024 Jan 16:2024.01.15.575794. doi: 10.1101/2024.01.15.575794. Preprint.

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2023

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Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interaction.

Majd A, Richter MN, Samuel RM, Cesiulis A, Ghazizadeh Z, Wang J, Fattahi F. medRxiv. 2023 Jun 5:2023.06.02.23290906. doi: 10.1101/2023.06.02.23290906. Preprint.

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Modeling enteric glia development, physiology and disease using human pluripotent stem cells.

Scantlen MD, Majd H, Fattahi F. Neurosci Lett. 2023 Aug 10;811:137334. doi: 10.1016/j.neulet.2023.137334. Epub 2023 Jun 12.

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Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy.

Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel AK, Okoye M, Scantlen MD, Tchieu J, Calder EL, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis JD, Chen S, Studer L, Fattahi F. Cell Stem Cell. 2023 May 4;30(5):632-647.e10. doi: 10.1016/j.stem.2023.04.006.

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Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.

Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F. bioRxiv. 2023 Mar 7:2023.03.06.531220. doi: 10.1101/2023.03.06.531220. Preprint.

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2022

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Programming multicellular assembly with synthetic cell adhesion molecules.

Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA. Nature. 2023 Feb;614(7946):144-152. doi: 10.1038/s41586-022-05622-z. Epub 2022 Dec 12.

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Diseased, differentiated and difficult: Strategies for improved engineering of in vitro neurological systems.

Elder N, Fattahi F, McDevitt TC, Zholudeva LV. Front Cell Neurosci. 2022 Sep 27;16:962103. doi: 10.3389/fncel.2022.962103. eCollection 2022.

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Stem Cell-Based Models for Studying the Effects of Cancer and Cancer Therapies on the Peripheral Nervous System.

Richter MN, Fattahi F. Adv Biol (Weinh). 2022 Sep;6(9):e2200009. doi: 10.1002/adbi.202200009. Epub 2022 Jun 4.

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A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells.

Ghazizadeh Z, Zhu J, Fattahi F, Tang A, Sun X, Amin S, Tsai SY, Khalaj M, Zhou T, Samuel RM, Zhang T, Ortega FA, Gordillo M, Moroziewicz D; NYSCF Global Stem Cell Array® Team; Paull D, Noggle SA, Xiang JZ, Studer L, Christini DJ, Pitt GS, Evans T, Chen S. iScience. 2022 Mar 25;25(4):104153. doi: 10.1016/j.isci.2022.104153. eCollection 2022 Apr 15.

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Androgens increase excitement in brain organoid research.

Samuel RM, Majd H, Richter MN, Fattahi F. Cell Stem Cell. 2022 Apr 7;29(4):495-497. doi: 10.1016/j.stem.2022.02.012.

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2021

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5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent.

Ghafouri-Fard S, Abak A, Tondro Anamag F, Shoorei H, Fattahi F, Javadinia SA, Basiri A, Taheri M. Front Oncol. 2021 Apr 19;11:658636. doi: 10.3389/fonc.2021.658636. eCollection 2021.

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The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders.

Ghafouri-Fard S, Abak A, Fattahi F, Hussen BM, Bahroudi Z, Shoorei H, Taheri M. Biomed Pharmacother. 2021 Jun;138:111519. doi: 10.1016/j.biopha.2021.111519. Epub 2021 Mar 20.

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Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL.

Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. Cancer Discov. 2021 Aug;11(8):2032-2049. doi: 10.1158/2159-8290.CD-20-0242. Epub 2021 Mar 16. PMID: 33727310

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Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy.

Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH. Stem Cell Reports. 2021 Mar 9;16(3):666-668. doi: 10.1016/j.stemcr.2021.01.012.

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2020

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Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel.

Xiong, C., Chua, K.C., Stage, T.B., Priotti, J., Kim, J., Altman‐Merino, A., Chan, D., Saraf, K., Canato Ferracini, A., Fattahi, F. and Kroetz, D.L. (2020). Clin Transl Sci. https://doi.org/10.1111/cts.12912

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Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. Cell Stem Cell. 2020 Dec 3;27(6):876-889.e12. doi:10.1016/j.stem.2020.11.009. Epub 2020 Nov 17. PMID: 33232663; PMCID: PMC7670929.

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Generation of Knockout Gene-Edited Human Intestinal Organoids.

Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD. Methods Mol Biol. 2020;2171:215-230. doi: 10.1007/978-1-0716-0747-3_13. PMID: 32705644.

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Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Ghazizadeh Z, Majd H, Richter M, Samuel R, Zekavat SM, Asgharian H, Farahvashi S, Kalantari A, Ramirez J, Zhao H, Natarajan P, Goodarzi H, Fattahi F. bioRxiv [Preprint]. 2020 May 15:2020.05.12.091082. doi: 10.1101/2020.05.12.091082. Update in: Cell Stem Cell. 2020 Nov 17;: PMID: 32511360; PMCID: PMC7263488.

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Roadmap for the Emerging Field of Cancer Neuroscience.

Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F. Cell. 2020 Apr 16;181(2):219-222. doi: 10.1016/j.cell.2020.03.034. PMID: 32302564; PMCID: PMC7286095.

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2019

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Derivation of enteric neuron lineages from human pluripotent stem cells.
Barber K, Studer L, Fattahi F. Nat Protoc. 2019 Apr;14(4):1261-1279. PMID: 30911172

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2018

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HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.

Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6. PMID: 30341316; PMCID: PMC6195591.

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Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy. 
Ghazizadeh Z*, Fattahi F*, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH. Stem Cell Reports. 2018 Mar 13;10(3):848-859. PMID: 29503094. *Equal contribution

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2017

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A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages.
Tchieu J*, Zimmer B*, Fattahi F*, Amin S, Zeltner N, Chen S, Studer L. Cell Stem Cell. 2017 Sep 7;21(3):399-410.e7. doi: 10.1016/j.stem.2017.08.015. PMID: 28886367. *Equal contribution

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Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L. Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23. PMID: 28112759; PMCID: PMC5516899.

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2016

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Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L. Nat Med. 2016 Dec;22(12):1421-1427. PMID: 27841875

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Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.
Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. Nature. 2016 Mar 3;531(7592):105-9. PMID: 26863197

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2015

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Neural Crest Cells from Dual SMAD Inhibition.
Fattahi F, Studer L, Tomishima MJ. Curr Protoc Stem Cell Biol. 2015 May 1;33:1H.9.1-9. PMID: 26344232